CR®-Technology
The patented CR® neuro-technology (CR® = coordinated reset) is an innovative approach to treating disorders that are characterised by excessive synchronous nerve cell activity. These disorders include, for instance, tinnitus, Parkinson's and epilepsy (1,2). Originally, CR® neuro-technology was derived from research on innovative brain pacemakers. The scientific basis was established over the course of more than ten years of scientific work at the Jülich Research Centre (Forschungszentrum Jülich, FZJ).
Specially clocked signals (CR® signals) that target the affected nerve cell assemblies disrupt their pathological synchrony to achieve desynchronisation (3,4). Repeating the desynchronisation process continuously causes the nerve cells to "unlearn" step by step how to engage in hyperactivity and synchrony (5,6). The targeted CR® signals can be transferred to the relevant areas of the brain by means of invasive (via electrodes) or sensory (non-invasive acoustic or tactile) intervention.
Today, CR® neuro-technology is already in practical use in the T30 CR® neurostimulator for chronic tonal tinnitus (acoustic CR® neuromodulation); a comprehensive clinical trial for applications to treat Parkinson's disease is in the planning phase and is expected to start in 2012.
Today, CR® neuro-technology is already in practical use in the T30 CR® neurostimulator for chronic tonal tinnitus (acoustic CR® neuromodulation); a comprehensive clinical trial for applications to treat Parkinson's disease is in the planning phase and is expected to start in 2012.
Further publications on CR® neuro-technology can be found under "Literature"
1 L. Roberts, J. Eggermont, D. Caspary, S. Shore, J. Melcher, J. Kaltenbach: Ringing Ears: The Neuroscience of Tinnitus; J Neurosci.; 30(45): 14972–14979 (2010)
2 L.Timmermann, J.Gross, M.Dirks, J.Volkmann, H.-J. Freund, and A. Schnitzler: The cerebral oscillatory network of parkinsonian resting tremor; Brain, 126, 199-212 (2003)
3 P. A. Tass: A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations; Biol. Cybern. 89, 81-88 (2003)
4 P.A. Tass: Desynchronization by Means of a Coordinated Reset of Neural Sub-Populations - A Novel Technique for Demand-Controlled Deep Brain Stimulation; Progress of Theoretical Physics Supplement 150, 281-296 (2003)
5 P. A. Tass and M. Majtanik: Long-term anti-kindling effects of desynchronizing brain stimulation: a theoretical study; Biol. Cybern. 94, 58-66 (2006)
6 C. Hauptmann and P.A. Tass: Cumulative and after-effects of short and weak coordinated reset stimulation: a modeling study. J. Neural Eng. 6 016004 (2009)
2 L.Timmermann, J.Gross, M.Dirks, J.Volkmann, H.-J. Freund, and A. Schnitzler: The cerebral oscillatory network of parkinsonian resting tremor; Brain, 126, 199-212 (2003)
3 P. A. Tass: A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations; Biol. Cybern. 89, 81-88 (2003)
4 P.A. Tass: Desynchronization by Means of a Coordinated Reset of Neural Sub-Populations - A Novel Technique for Demand-Controlled Deep Brain Stimulation; Progress of Theoretical Physics Supplement 150, 281-296 (2003)
5 P. A. Tass and M. Majtanik: Long-term anti-kindling effects of desynchronizing brain stimulation: a theoretical study; Biol. Cybern. 94, 58-66 (2006)
6 C. Hauptmann and P.A. Tass: Cumulative and after-effects of short and weak coordinated reset stimulation: a modeling study. J. Neural Eng. 6 016004 (2009)
Last Updated ( Wednesday, 11 July 2012 08:57 )
